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胡海洋特聘副研究员在较量争论演变生物学与分子生物学权势巨子期刊Molecular Biology and Evolution揭橥最新协作研究成果

相干浏览:胡玉斌 个人简介: 胡玉斌,男,陆地化学专业。现任山东大学陆地研究院副研究员,硕士研究生导师。 首要从事海冰生物地球化学、陆地碳循环及陆地酸化研讨,屡次介入两极及中国远洋…

相干浏览:胡玉斌

个人简介:

胡玉斌,男,陆地化学专业。现任山东大学陆地研究院副研究员,硕士研究生导师。

胡海洋

首要从事海冰生物地球化学、陆地碳循环及陆地酸化研讨,屡次介入两极及中国远洋科考。 在海冰碳化学研讨进程中,开辟了一种新型疾速的海冰消融无机碳收集方式;零碎地舆清了ikaite在海冰中的成因前提;并初次提出ikaite的构成对磷酸盐有共沉降感化,拓荒的海冰生物地球化学进程的研讨新偏向。今朝的研讨还触及经由过程地球工程手腕测验考试找到减缓陆地酸化及完成陆地增汇的方式。

E-mail: yubinhu@sdu.edu.cn

Abstract:

Dr. Yubin Hu, Associate Research Scientist at the Institute of Marine Science and Technology, Shandong University.

Dr. Hu majored in Marine Chemistry. His research focuses on sea ice biogeochemistry, marine carbon cycle and ocean acidification. He has rich experience in Polar and near sea expedition. During his research in sea ice carbon chemistry, he developed a new simple method for sea ice DIC sampling; clarified the conditions leading to ikaite formation in sea ice; proposed a hypothesis that ikaite could co-precipitate phosphate in sea ice, which opens a new research area on sea ice biogeochemistry. His current work also includes mitigating ocean acidification as well as enhancing marine carbon sink by means of geoengineering.

进修任务履历:

中国海洋大学学士 (2003-2007)

中国海洋大学和不莱梅大学双硕士 (2007-2010)

不莱梅大学博士 (2010-2013)

胡海洋

德国极地与陆地研究所博士后 (2014)

加拿大曼尼托巴大学博士后 (2014-2016)

山东大学副研究员 (2016-)

Experiences:

B.S., Ocean University of China (2003-2007)

Double M.Sc., Ocean University of China and University of Bremen (2007-2010)

Ph.D., University of Bremen (2010-2013)

Postdoctoral Fellow, Alfred Wegener Institute for Polar and Marine Research, Germany (2014)

Postdoctoral Fellow, University of Manitoba, Canada (2014-2016)

Associate Research Scientist, Shandong University (2016-)

研讨偏向:

海冰生物地球化学,陆地碳循环,陆地酸化

Research Interests:

Sea-ice Biogeochemistry, Marine Carbon Cycle, Ocean Acidification

代表性著作/Selected Publications:

1. Hu, Y.-B., F. Wang, W. Boone, D. Barber and S. Rysgaard. Assessment and improvement of the sea ice processing for dissolved inorganic carbon analysis, Limnology and Oceanography: Methods, 2018, 16(2): 83~91.

2. Bendtsen, J., J. Mortensen, K. Lennert, J. K. Ehn, W. Boone, V. Galindo, Y.-B. Hu, I. A. Dmitrenko, S. A. Kirillov, K. K. Kjeldsen, Y. Kristoffersen, D. Barber and S. Rysgaard. Sea ice breakup and marine melt of a retreating tidewater outlet glacier in northeast Greenland (81 degrees N), Scientific Reports, 2017, 7.

3. Hu, Y.-B., M. Wolthers, D. A. Wolf-Gladrow and G. Nehrke. Effect of pH and phosphate on calcium carbonate polymorphs precipitated at near-freezing temperature, Crystal Growth & Design, 2015, 15(4): 1596~1601.

4. Hu, Y.-B., C.-Y. Liu, G.-P. Yang and H.-H. Zhang. The response of the carbonate system to a green algal bloom during the post-bloom period in the southern Yellow Sea, Continental Shelf Research, 2015, 94: 1~7.

5. Hu, Y.-B., G. S. Dieckmann, D. A. Wolf-Gladrow and G. Nehrke. Laboratory study on coprecipitation of phosphate with ikaite in sea ice, Journal of Geophysical Research-Oceans, 2014, 119(10): 7007~7015.

6. Hu, Y.-B., D. A. Wolf-Gladrow, G. S. Dieckmann, C. Völker and G. Nehrke. A laboratory study of ikaite (CaCO3.6H2O) precipitation as a function of pH, salinity, temperature and phosphate concentration, Marine Chemistry, 2014, 162: 10~18.

7. Nomura, D., P. Assmy, G. Nehrke, M. A. Granskog, M. Fischer, G. S. Dieckmann, A. Fransson, Y.-B. Hu and B. Schnetger. Characterization of ikaite (CaCO3.6H2O) crystals in first-year Arctic sea ice north of Svalbard, Annals of Glaciology, 2013, 54(62): 125~131.

8. 胡玉斌,刘春颖,杨桂朋,张洪海,春季东海和南黄海表层海水CO2系统各参数散布及海—气界面通量。中国海洋大学学报(自然科学版), 2010, 40(2): 73~78.近日,较量争论演变生物学与分子生物学权势巨子期刊Molecular Biology and Evolution(2018,35(5),1063-1077;影响因子:10.217)揭橥了我校生命科学与手艺学院胡海洋特聘副研究员与云南大学俞海菁传授和中国科学院德国马普较量争论生物学研究所所长PhilippKhaitovich传授的协作研究成果《Recently Evolved Tumor Suppressor Transcript TP73-AS1 Functions as Sponge of Human-Specific miR-941》。我校胡海洋特聘副研究员为本文的第一作者,中国药科大学为本文第一单元。

在此前的任务中,胡海洋特聘副研究员经由过程数据挖掘发明了首个人类特有microRNA miR-941并解析了其发源演变进程和及其调控大脑发育的份子机制,相干研究成果揭橥在Nature Communications(2012,3,1145-1154)上。本论文在前期工作根蒂根基上,依托生物组学和基因组大数据,采取较量争论调控基因组学与演变生物学相结合的零碎生物学研讨体式格局进一步深入研究了随同miR-941发源的疾速演变长琏非编码RNA TP73-AS1及其与癌症产生成长的联系关系。该研讨任务起首开辟了microRNA sponge基因较量争论生物学猜测方式,周全猜测了调控miR-941表达的sponge基因,个中TP73-AS1得分最高。接着经由过程时候序列剖析和细胞分子生物学实行,验证了TP73-AS1可以高效调控miR-941表达且与细胞迁徙功用密切相关。最初经由过程整合大规模组学数据,胜利揭露了TP73-AS1与miR-941的调控收集与多种癌症之间的联系关系。

此项研讨不但开辟了可以猜测microRNA潜伏sponge基因的较量争论生物学方式,并且也为人类绝对于非人灵长类植物的癌症易感性供应了潜伏份子靶标。该研究型论文被期刊以”fast track”体式格局揭橥。

(供稿单元:生命科学与手艺学院,撰写人:胡海洋)

相干浏览:胡海洋

姓名:胡海洋

性别:男

籍贯:辽宁省大连市

联系电话:024-43520545

E-Mail:haiyang_hu@hotmail.com

职称/职务:副教授

通讯地址:沈阳市沈河区文化路103号沈阳药科大学42号信箱

邮政编码:110016

招收专业:100702药剂学(硕士)、105502药学(药剂学偏向)(硕士)

小我情形引见、概览

胡海洋,男,博士,副教授。2000年卒业于沈阳药科大学,获药物制剂学士学位,2006年于同校获药剂学博士学位,2006年于沈阳药科大学药剂教研室任教,讲师,2013年被聘为沈阳药科大学副教授,硕士生导师,2016赴美国University of North Carolina at Chapel Hill停止访问学者研讨。作为课题负责人掌管了国家自然科学基金青年基金项目1项,辽宁省教育厅项目2项,别的,作为项目骨干成员承当国家自然科学基金面上项目3项。今朝已在IJP,Biomaterial,Acta biomaterialia等期刊揭橥论文20余篇。

人才网job.vhao.net称号、社会兼职等

1.中国中医药学会制剂分会委员;

2.高等学校杰出青年学者生长设计;

首要研讨偏向

研讨偏向一:自动靶向制剂的设计及机理研讨

研讨偏向二:新型基因传递零碎的研讨

研讨偏向三:肿瘤免疫治疗的研讨

掌管、介入的科研项目(含科研获奖等情形)

1. pH敏感PAMAM衍生物作为基因药物载体的研讨,高等学校杰出青年学者生长设计,辽宁省教育厅,2014.1-2016.12。(项目负责人)

2.人工重组低密度脂蛋白肿瘤靶向纳米脂质载体的研讨,国家自然科学基金青年基金,81102400,2012-2014。(项目负责人)

3.具有肿瘤靶向和pH敏感释药的壳聚糖共聚物胶束的研讨,辽宁省教育厅普通项目,L2010528,2010.1~2013.12。(项目负责人)

4.复合机制介导自组装共保送药物传递载体的构建及机制研讨,国家自然科学基金青年基金81202483 2013.1-2015.12。

5 .胍基化SS-PAAs新型基因载体的研讨,国家自然科学基金面上项目(81373335),2014.1~2017.12。

6.复方奥美拉唑干混悬剂处方工艺研讨,横向研讨2012-0-4-072,2012.9-2013.5。

7.复方阿斯匹灵肠溶胶囊的研讨,横向研讨,2016.9-2017.9。

近年来揭橥代表性论文(限第一作者或通信作者,SCI须写明影响因子):

1. LiW, Zhang X, Jing S, Xin X, Chen K, Chen D,Hu H*.Organic metal complexes based onzoledronate–calcium: a potential pDNA delivery system. J. Mater. Chem. B. 2017,5(8): 1601-1610. (IF=4.543)(通信作者)

2. Zhang M,Jing S, Zhang, Jiulong Zhang J, Zang X, Zhao X,Qiao X,Hu H*and Chen D. Intracellular release of PluronicL64 unimers into MCF-7/ADRcells to overcome multidrug resistance by surface-modified PAMAM. J. Mater.Chem. B2017,5, 3970-3981. (IF=4.543) (通信作者)

3. LiW, Zhang X, Jing S, Xin X, Chen K, Chen D,Hu H*. Preparation of CalciumPhosphate/pDNA Nanoparticles for Exogenous Gene Delivery by Co-PrecipitationMethod: Optimization of Formulation Variables Using Box-Behnken Design. J PharmSci, 2017,106 (8):2053-2059. (IF=2.713) (通信作者)

4.Chen K, Guo L, Zhang J, Chen Q, Wang K, LiC, Li W, Qiao M, Zhao X,Hu H*, Chen D.A genedelivery system containing nuclear localization signal: Increased nucleusimport and transfection efficiency with the assistance of RanGAP1.Acta Biomaterialia, 2017,48:215-226. (IF=6.319) (通信作者)

5. zhang J,Liu D, Zhang M, Sun Y, Zhang X, Guan G, Zhao X, Qiao M, Chen D,Hu H*. The cellular uptake mechanism,intracellular transportation, and exocytosis of polyamidoamine dendrimers inmultidrug-resistant breast cancer cells. Int J Nanomedicine, 2016, 11:3677-90.(IF=4.3) (通信作者)

6.ChenK, Chen Q, Wang K, Zhu J, Li W, Li W, QiuL, Guan G, Qiao M, Zhao X,Hu H*, Chen D Synthesis and characterization of a PAMAM-OHderivative containing an acid-labileβ-thiopropionate bond for gene delivery.International Journal of Pharmaceutics. 2016,509 (1–2): 314-327. (IF=4.3) (通信作者)

7. WangM,Hu H*, Sun Y, QiuL, Zhang J, Guan G, Zhao X, Qiao M, ChengL, Cheng L, Chen D. A pH-sensitive gene delivery system based onfolic acid-PEG-chitosan – PAMAM-plasmid DNA complexes for cancer celltargeting.Biomaterials,2013, 34(38), 10120-10132. (IF=7.6) (通信作者)

8. Liu D,HuH*, Lin Z, Chen D, Zhu Y, Hou S,Shi X. Quercetindeformable liposome: Preparation and efficacy against ultraviolet B inducedskin damages in vitro and in vivo. J Photochem Photobiol B, 2013, 127, 8-17. (IF=3.11)(配合第一作者)

9.Hu H*, LiuD, Zhao X, Qiao M, Chen D. Preparation, characterization, cellularuptake and evaluation in vivo of solid lipid nanoparticles loaded withcucurbitacin B. Drug Dev Ind Pharm,2013, 39 (5) :770-779. (IF=1.5) (第一作者)

10.顾莹熙,胡海洋*等.拟低密度脂蛋白脂质焦点的制备及性质考查.沈阳药科大学学报, 2014, 31(4): 241. (通信作者)

专利及其他

1.胡海洋,陈大为.一种注射用复合维生素亚微乳粉针剂及其制备方式. ZL201110456626.X,受权.

2.胡海洋,陈大为.一种盐酸甲氯芬酯胃漂浮缓释胶囊及制备方式. CN101229149 B,受权.

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